The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication.

@article{Kwun2009TheMR,
  title={The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication.},
  author={Hyun Jin Kwun and Anna Guastafierro and Masahiro Shuda and Gretchen Meinke and Andrew Bohm and Patrick S Moore and Yuan - Chia Chang Yeun - Chung Chang Chin - Chen Chang},
  journal={Journal of virology},
  year={2009},
  volume={83 23},
  pages={12118-28}
}
Merkel cell polyomavirus (MCV) is a recently discovered human polyomavirus causing the majority of human Merkel cell carcinomas. We mapped a 71-bp minimal MCV replication core origin sufficient for initiating eukaryotic DNA replication in the presence of wild-type MCV large T protein (LT). The origin includes a poly(T)-rich tract and eight variably oriented, GAGGC-like pentanucleotide sequences (PS) that serve as LT recognition sites. Mutation analysis shows that only four of the eight PS are… CONTINUE READING
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Polyomavirinae: the viruses and their replication, p. 2141–2174

  • C. N. Cole, S. D. Conzen
  • Fields virology,
  • 2001
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