The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

@inproceedings{Manning2010TheMK,
  title={The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology},
  author={Gerard Manning and David S. Reiner and Tineke Lauwaet and Michael Dacre and Alias J Smith and Yufeng Zhai and Staffan Jacobsson Svard and Frances D. Gillin},
  booktitle={Genome Biology},
  year={2010}
}
The major human intestinal pathogen Giardia lamblia is a very early branching eukaryote with a minimal genome of broad evolutionary and biological interest. To explore early kinase evolution and regulation of Giardia biology, we cataloged the kinomes of three sequenced strains. Comparison with published kinomes and those of the excavates Trichomonas vaginalis and Leishmania major shows that Giardia's 80 core kinases constitute the smallest known core kinome of any eukaryote that can be grown in… CONTINUE READING
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