The minimal functional sequence of protamine.

@article{Liang2005TheMF,
  title={The minimal functional sequence of protamine.},
  author={Jun Liang and Victor C Yang and Yekaterina Vaynshteyn},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={336 2},
  pages={653-9}
}
Despite its nearly universal applications, protamine, a mixture of four major peptides with different sequences, is associated with clinically significant side effects. Through a well-designed enzyme digestion method, various low molecular weight protamine peptides were obtained. Among them, two low molecular weight protamine peptides with the same or even more potent heparin neutralization abilities as native protamine were identified through both in vitro and in vivo tests. In addition, in… CONTINUE READING

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