The million mutation project: a new approach to genetics in Caenorhabditis elegans.

@article{Thompson2013TheMM,
  title={The million mutation project: a new approach to genetics in Caenorhabditis elegans.},
  author={Owen A. Thompson and Mark L Edgley and Pnina Strasbourger and Stephane Flibotte and Brent Ewing and Ryan Adair and Vinci Au and Iasha Chaudhry and L. B. Fernando and Harald Hutter and Armelle Kieffer and Joanne Lau and Norris Lee and A. Miller and Greta C. Raymant and Bin Shen and Jay Shendure and Jon Taylor and Emily H Turner and LaDeana W. Hillier and Donald G. Moerman and Robert H. Waterston},
  journal={Genome research},
  year={2013},
  volume={23 10},
  pages={1749-62}
}
We have created a library of 2007 mutagenized Caenorhabditis elegans strains, each sequenced to a target depth of 15-fold coverage, to provide the research community with mutant alleles for each of the worm's more than 20,000 genes. The library contains over 800,000 unique single nucleotide variants (SNVs) with an average of eight nonsynonymous changes per gene and more than 16,000 insertion/deletion (indel) and copy number changes, providing an unprecedented genetic resource for this… CONTINUE READING
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