The migration of divalent cations in mitochondria visualized by a fluorescent chelate probe

@article{Caswell1972TheMO,
  title={The migration of divalent cations in mitochondria visualized by a fluorescent chelate probe},
  author={Anthony H. Caswell},
  journal={The Journal of Membrane Biology},
  year={1972},
  volume={7},
  pages={345-364}
}
The use of the fluorescent chelate probe, chlorotetracycline, in mitochondria is described. The probe shows a high fluorescence in the presence of mitochondria which may be ascribed to binding of the probe to membrane-associated Ca++ and Mg++. The fluorescence excitation and emission spectra are diagnostic of binding of the probe to Ca++ in coupled mitochondria and Mg++ in uncoupled mitochondria. The fluorescence polarization spectra are diagnostic of the cations having a moderately high… CONTINUE READING
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Enhancement of ethidium bromide fluorescence as a probe of membrane structure

  • A. H. Caswell, C. Gitler
  • Fed. Proc. 29:605. (Abstr.)
  • 1970

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