The migrating motor complex: control mechanisms and its role in health and disease

  title={The migrating motor complex: control mechanisms and its role in health and disease},
  author={Eveline Deloose and Pieter Janssen and Inge Depoortere and Jan Tack},
  journal={Nature Reviews Gastroenterology \&Hepatology},
The migrating motor complex (MMC) is a cyclic, recurring motility pattern that occurs in the stomach and small bowel during fasting; it is interrupted by feeding. The MMC is present in the gastrointestinal tract of many species, including humans. The complex can be subdivided into four phases, of which phase III is the most active, with a burst of contractions originating from the antrum or duodenum and migrating distally. Control of the MMC is complex. Phase III of the MMC with an antral… 

Importance of the enteric nervous system in the control of the migrating motility complex.

The main goal of this article was to discuss the importance of intrinsic innervation of the gastrointestinal tract in MMC initiation, migration, and cessation to emphasize that various MMC-controlling mechanisms act through the enteric nervous system.

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling.

  • E. DelooseJ. Tack
  • Medicine
    American journal of physiology. Gastrointestinal and liver physiology
  • 2016
The functions of the MMC in the gut and its regulatory role in controlling hunger sensations are described and it is suggested that these motilin-induced phase III contractions signal hunger in healthy subjects and that this system is disturbed in morbidly obese patients.

Underlying mechanism of the cyclic migrating motor complex in Suncus murinus: a change in gastrointestinal pH is the key regulator

A clear insight mechanism is suggested that change in the duodenal pH to alkaline condition is an essential factor for stimulating the endogenous release of motilin and governs the fasting MMC in a vagus‐independent manner.

Physiology, Gastrocolic Reflex

The sigmoid colon is the region most affected during the phasic response of digestion, which consists of cyclical periods of contraction followed by relaxation to propel food distally toward the rectum.

Gastrointestinal Motor Function

This chapter aims to identify the course and key milestones in GI motility research and lays down basic concepts and principles of motility of different regions of the gut and their relationship to the maintenance of the functioning of digestion.

Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility

The structure, distribution, receptor and the GI motility regulatory function of motilin in vertebrates from fish to mammals is reviewed.

Motilin-induced gastric contractions signal hunger in man

Motilin-induced gastric phase III is a hunger signal from GIT in man, and the role of phase III was also studied in the return of hunger after a meal in healthy individuals and in patients with loss of appetite.

Food and Symptom Generation in Functional Gastrointestinal Disorders: Physiological Aspects

The response of the gastrointestinal tract (GIT) to ingestion of food is a complex and closely controlled process, which allows optimization of propulsion, digestion, absorption of nutrients, and

The influence of gastric motility on the intraluminal behavior of fosamprenavir.

Enteric and Central Nervous System Mediated Control of Digestive Processes in the Small Intestine: a Coprocessor-Processor Paradigm

The nature of regulating mechanisms that are managed partly by the enteric nervous system as analogous to a coprocessor and works in conjunction with the central nervous system (CNS), the primary processor to manage the extensive task of digesting the meal are explored.



A migrating electric complex of canine small intestine.

A migrating electric complex that occurs in fasting dogs is described, composed of a consecutive series of slow waves, on each of which is superimposed a burst of Iargeamplitude action potentials that distinguish it from other electric activity in the small bowel of fasting dogs.

Meaningful or redundant complexity – mechanisms behind cyclic changes in gastroduodenal pH in the fasting state

The antroduodenal region is probably the site of the most common chronic infection of mankind, helicobacter‐induced antral gastritis, and the role of the gastric mucus layer in antral Helicobacter infection is discussed.

Serotonin regulation of the canine migrating motor complex.

Exogenous serotonin affects motor activity during MMC phases II and III and appears to be a candidate regulator of the intrinsic mechanisms governing the initiation and propagation of the canine MMC.

Variability of migrating motor complex in humans

It is concluded that human MMC activity varies widely between individuals and within the same individual when studied on separate days.

Chagas' disease: a model of denervation in the study of digestive tract motility.

  • U. Meneghelli
  • Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 1985
A better understanding of the participation of the ENS in the regulation of the normal motor activities of the digestive tract is provided and this has led to the conclusion that Chagas' disease is a true model of intrinsic denervation of the human digestive tract.

The patterns of motility are maintained in the human small intestine throughout the process of aging.

The patterns of motility are maintained in the human small intestine throughout the process of aging, as were the amplitude and frequency of contractions during phase III and the postprandial state.

Motilin-induced mechanical activity in the canine alimentary tract.

The view that the interdigestive gastrointestinal motor activity is at least in part regulated by circulating motilin concentration in the blood, however, its cyclic recurring, caudad propagating mechanism may be controlled in part by the nervous system is strongly suggested.