The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice.

@article{Toribio2010TheMN,
  title={The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice.},
  author={Ramiro E. Toribio and Holly A. Brown and Chad M. Novince and Brandlyn Marlow and Krista M. Hernon and Lisa G. Lanigan and Blake E Hildreth and Jillian L. Werbeck and Sherry T. Shu and Gwendolen Lorch and Michelle M Carlton and John Foley and Prosper N Boyaka and L. McCauley and Thomas J Rosol},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 6},
  pages={1947-57}
}
The functions of parathyroid hormone-related protein (PTHrP) on morphogenesis, cell proliferation, apoptosis, and calcium homeostasis have been attributed to its N terminus. Evidence suggests that many of these effects are not mediated by the N terminus but by the midregion, a nuclear localization sequence (NLS), and C terminus of the protein. A knock-in mouse lacking the midregion, NLS, and C terminus of PTHrP (Pthrp(Delta/Delta)) was developed. Pthrp(Delta/Delta) mice had craniofacial… CONTINUE READING