The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study.

@article{Ritchie2017TheMC,
  title={The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study.},
  author={Karen Ritchie and Isabelle Carri{\`e}re and Li Su and John T. O'Brien and Simon Lovestone and Katie Wells and Craig William Ritchie},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year={2017},
  volume={13 10},
  pages={1089-1097}
}
INTRODUCTION Although biomarker studies of late-onset Alzheimer's disease suggest pathology to be present decades before diagnosis, little is known about cognitive performance at this stage. METHODS A sample of 210 adults (aged 40-59) of whom 103 have a parent diagnosed with dementia (family history subgroup) underwent computerized cognitive testing. Apolipoprotein E (apoE) status was determined, and 193 subjects had magnetic resonance imaging. Distance from dementia onset was estimated in… CONTINUE READING
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