The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.

@article{Zhang2012TheMA,
  title={The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.},
  author={Bin Zhang and Jenna Carroll and John Q. Trojanowski and Yuemang Yao and Michiyo Iba and Justin Potuzak and Anne-Marie L Hogan and Sharon X Xie and Carlo Ballatore and Amos B. Smith and Virginia M-Y Lee and Kurt R. Brunden},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 11},
  pages={3601-11}
}
Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased phosphorylation and decreased solubility has been proposed to diminish normal tau stabilization of microtubules (MTs), thereby leading to neuronal dysfunction. Earlier studies have provided evidence that small molecule MT-stabilizing drugs that are used in the treatment of cancer may have utility in the treatment of… CONTINUE READING
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