The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization.

@article{Ligon2003TheMP,
  title={The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization.},
  author={Lee A. Ligon and Spencer S. Shelly and Mariko K. Tokito and Erika L. F. Holzbaur},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 4},
  pages={
          1405-17
        }
}
Several microtubule-binding proteins including EB1, dynactin, APC, and CLIP-170 localize to the plus-ends of growing microtubules. Although these proteins can bind to microtubules independently, evidence for interactions among them has led to the hypothesis of a plus-end complex. Here we clarify the interaction between EB1 and dynactin and show that EB1 binds directly to the N-terminus of the p150(Glued) subunit. One function of a plus-end complex may be to regulate microtubule dynamics… CONTINUE READING