The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation.

@article{Kunert2009TheMM,
  title={The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation.},
  author={Stefan Kunert and Imke Meyer and Silke Fleischhauer and Martin Wannack and Janine Fiedler and Ramesh A. Shivdasani and Harald Schulze},
  journal={Blood},
  year={2009},
  volume={114 27},
  pages={
          5532-40
        }
}
Terminally mature megakaryocytes undergo dramatic cellular reorganization to produce hundreds of virtually identical platelets. A hallmark feature of this process is the generation of an elaborate system of branched protrusions called proplatelets. We recently identified RanBP10 as a tubulin-binding protein that is concentrated along polymerized microtubules in mature megakaryocytes. RanBP10 depletion in vitro caused the disturbance of polymerized filaments. Here we study the function of… CONTINUE READING

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