The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2

@inproceedings{Zou2013TheMP,
  title={The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2},
  author={Weiguo Zou and Matthew Blake Greenblatt and Nicholas Brady and Sutada Lotinun and Bo Zhai and Heather de Rivera and Anju Singh Anju Singh and Jianhua Sun and Steven P Gygi and Roland Baron and L. H. Glimcher and Dallas Jones},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Osteoblasts are responsible for the formation and mineralization of the skeleton. To identify novel regulators of osteoblast differentiation, we conducted an unbiased forward genetic screen using a lentiviral-based shRNA library. This functional genomics analysis led to the identification of the microtubule-associated protein DCAMKL1 (Doublecortin-like and CAM kinase-like 1) as a novel regulator of osteogenesis. Mice with a targeted disruption of Dcamkl1 displayed elevated bone mass secondary… CONTINUE READING

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DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization.

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