The microsomal dealkylation of N,N-dialkylbenzamides.


The in vitro metabolism of N,N-dialkylamides by phenobarbital-induced rat liver microsomes yields an N-alkylamide and the corresponding aldehyde. Although, N-hydroxymethyl-N-alkylamide intermediates can be detected from N-methyl-N-alkylamides, no N-hydroxyalkyl-N-alkylamide intermediates are detected from the N,N-dialkylamide substrates. Vmax values were… (More)


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