The microinjection of a cannabinoid agonist into the accumbens shell induces anxiogenesis in the elevated plus-maze

@article{Kochenborger2014TheMO,
  title={The microinjection of a cannabinoid agonist into the accumbens shell induces anxiogenesis in the elevated plus-maze},
  author={Larissa Kochenborger and Brunno Rocha Levone and Eduardo Moreira da Silva and Ana Paula Dambros Taschetto and Moacir Serralvo Faria},
  journal={Pharmacology Biochemistry and Behavior},
  year={2014},
  volume={124},
  pages={160-166}
}
This study investigated the effect of a cannabinoid agonist injected into the shell region of the nucleus accumbens (nAcb shell) on anxiety-related behaviors. The animals (male Wistar rats) were unilaterally microinjected with either ACEA (arachidonyl-2'-chloroethylamide a CB1 receptor agonist) at doses of 0.005, 0.05 or 0.5 pmol, or vehicle (ethanol 0.04% in saline 0.9%) and submitted to the elevated plus-maze (EPM), a pre-clinical test of anxiety. The data showed that rats microinjected with… CONTINUE READING