The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro.

@article{McNatty1979TheMO,
  title={The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro.},
  author={Kenneth P. McNatty and Donald Mitchell Smith and Anastasia Makris and Rapin Osathanondh and Kenneth John Ryan},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1979},
  volume={49 6},
  pages={
          851-60
        }
}
A number of parameters in human antral follicles were investigated. They were: the number of granulosa cells in each follicle; the concentrations of progesterone, androstenedi-one, testosterone, dihydrotestosterone, estrone, and 17β-estra-diol in antral fluid; and the status of the oocyte immediately after removal from the follicle and again after 48 h in culture. In addition, the phase of the menstrual cycle at the time of ovariectomy and the diameter of each dissected follicle were recorded… Expand
The human antral follicle : Functional correlates of growth and atresia
This communication reviews the current information on the developmental relationships between the various tissues of the growing human antral follicle. It also examines the various interrelationshipsExpand
Hormonal correlates of follicular development in the human ovary.
  • K. McNatty
  • Biology, Medicine
  • Australian journal of biological sciences
  • 1981
TLDR
It is concluded that the fate of a developing antral follicle centers around its ability to generate an oestrogen-enriched intrafollicular environment while simultaneously secreting both androgens and oestrogens into ovarian-venous blood. Expand
The production of progesterone, androgens and oestrogens by human granulosa cells in vitro and in vivo.
TLDR
It is concluded that Steroidogenesis by the human follicle is not rigidly compartmentalized between the theca and granulosa cell-types, and it is suggested that thegranulosa cells have a major influence in determining the level of steroid in antral fluid. Expand
Relationship among the status of the human oocyte, the 17 beta-estradiol concentration in the antral fluid and the follicular size.
TLDR
It seems that the follicle containing a degenerative oocyte does not develop physiologically until maturation of the preovulatory follicle, and the results suggest that the corpus luteum may exert an influence on the adjacent follicles. Expand
Influence of human chorionic gonadotropin in vivo on steroid formation and gonadotropin responsiveness of isolated human preovulatory follicular cells.
TLDR
Exposure to hCG in vivo caused a shift in steroidogenesis from A toward P formation in isolated thecal cells and a marked increase in the P production by the granulosa cells of the preovulatory follicles. Expand
Preovulatory follicular development in sheep treated with PMSG and/or prostaglandin.
TLDR
The results showed that a large 'oestrogenic' follicle appears around 10 h after the cloprostenol injection and that this presumptive preovulatory follicle emerges before the corpus luteum has ceased to function. Expand
Relationship between plasma prolactin and the endocrine microenvironment of the developing human antral follicle.
  • K. McNatty
  • Biology, Medicine
  • Fertility and sterility
  • 1979
TLDR
It is suggested that hyperprolactinemia is associated with a marked reduction in intraovarian activity and that the extent of this reduction may not be always apparent from the levels of circulating estradiol. Expand
Effects of luteinizing hormone on steroidogenesis by thecal tissue from human ovarian follicles in vitro
Abstract The steroidogenic responsiveness of human thecal tissue to different doses of LH was investigated in vitro in relation to the health of the follicle and to the responsiveness of stromalExpand
Granulosa and thecal cells from human ovarian follicles under growth: steroid formation in vitro and responsiveness to human chorionic gonadotropin
TLDR
Tissue cyclic AMP levels and medium content of progesterone, androstenedione and estradiol-17β were determined, and thecal cells from both small and large follicles increased their production of cAMP in the presence of hCG. Expand
Follicular development during the luteal phase of the human menstrual cycle.
TLDR
The data suggest that the number of healthy luteal phase follicles available for subsequent preovulatory development is limited, and healthy (lutealphase) follicles were not distinguishable from atretic follicles. Expand
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It was found that granulosa cells, thecal tissue, and stromal tissue all have the biosynthetic capacity to produce P, delta 4, testosterone, dihydrotestosterone, estrone, and E2, and no individual steroid-secreting compartment of the ovaries studied had the exclusive capability of producing any of the above-named steroids. Expand
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It is suggested that in human ovaries up to 90% of the oestradiol in follicular fluid may originate from the granulosa cells. Expand
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It is suggested that after the initiation of follicular development by FSH, a long period of exposure to both FSH and oestradiol is necessary before the maximum biosynthetic capacity of granulosa cells is achieved; this synthetic potential is then only realized under the influence of LH and prolactin. Expand
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There was a progressive overall increase in the steroid concentration of antral fluids of individual follicles related to their growth during proliferative phase, and progesterone concentration was relatively increased in follicles of 7–8 mm diameter. Expand
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Levels of progesterone, 17alpha-hydroxyprogesterone and oestradiol-17beta in follicular fluid were high in preovulatory follicles in comparison with plasma, and results in two patients indicated that plasma levels of these steroids were determined by the preovatory follicle. Expand
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Cellular sites and gonadotropic control of human follicular estrogen secretion have been assessed by culturing the theca and granulosa components separately under different hormonal conditions.Expand
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TLDR
Conditions in which the process of ovulation is dissociated from nuclear maturation of the germ cell, resulting in the shedding of a primary oocyte are described. Expand
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TLDR
It is suggested that the relatively low concentration of androstenedione in follicular fluid of the preovulatory follicle arises from increased aromatization by granulosa cells in the course of oestrogen synthesis. Expand
Changes in the concentration of pituitary and steroid hormones in the follicular fluid of human graafian follicles throughout the menstrual cycle.
TLDR
It is suggested that a precise sequence of hormonal changes occur within the microenvironment of the developing Graafian follicle; the order in which they occur may be of considerable importance for the growth of that follicle and secretory activity of the granulosa cells both before and after ovulation. Expand
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  • Chemistry, Medicine
  • The Journal of clinical endocrinology and metabolism
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TLDR
The conversion of pregnenolone to progesterone was much more active with the granulosa than the theca, while indications of an alternate pathway via Δ5 compounds were more apparent with thecal cells. Expand
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