The microenvironment matters: estrogen deficiency fuels cancer bone metastases.

Abstract

Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 2817-9. ©2014 AACR.

DOI: 10.1158/1078-0432.CCR-14-0576

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Cite this paper

@article{Wright2014TheMM, title={The microenvironment matters: estrogen deficiency fuels cancer bone metastases.}, author={Laura E. Wright and Theresa A. Guise}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2014}, volume={20 11}, pages={2817-9} }