The microbiota regulates type 2 immunity through RORγt+ T cells

  title={The microbiota regulates type 2 immunity through RORγt+ T cells},
  author={Caspar Ohnmacht and Joo-Hong Park and Sascha Cording and James Badger Wing and Koji Atarashi and Yuuki Obata and Val{\'e}rie Gaboriau-Routhiau and Rute Marques and Sophie Dulauroy and Maria Fedoseeva and Meinrad Busslinger and Nadine Cerf-Bensussan and Ivo G Boneca and David Voehringer and Koji Hase and Kenya Honda and Shimon Sakaguchi and G{\'e}rard Eberl},
Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (TH17) cells and regulatory T cells (Tregs) in the intestine. Here, we report that microbiota-induced Tregs express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to TH17 cells. In the absence of… CONTINUE READING


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