The microbiota in adaptive immune homeostasis and disease

@article{Honda2016TheMI,
  title={The microbiota in adaptive immune homeostasis and disease},
  author={K. Honda and D. Littman},
  journal={Nature},
  year={2016},
  volume={535},
  pages={75-84}
}
  • K. Honda, D. Littman
  • Published 2016
  • Biology, Medicine
  • Nature
  • In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from… CONTINUE READING
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    References

    SHOWING 1-10 OF 167 REFERENCES
    Regulatory T cells: mechanisms of differentiation and function.
    • 1,897
    • PDF
    The microbiota regulates type 2 immunity through RORγt+ T cells
    • 390
    • PDF
    Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • 1,463
    • PDF
    Microbiota regulates immune defense against respiratory tract influenza A virus infection
    • 822
    • PDF
    Compartmentalized Control of Skin Immunity by Resident Commensals
    • 651
    • PDF