The microbiome of the urinary tract—a role beyond infection

@article{Whiteside2015TheMO,
  title={The microbiome of the urinary tract—a role beyond infection},
  author={Samantha A. Whiteside and Hassan A. Razvi and Sumit Dav{\'e} and Gregor Reid and Jeremy P. Burton},
  journal={Nature Reviews Urology},
  year={2015},
  volume={12},
  pages={81-90}
}
Urologists rarely need to consider bacteria beyond their role in infectious disease. However, emerging evidence shows that the microorganisms inhabiting many sites of the body, including the urinary tract—which has long been assumed sterile in healthy individuals—might have a role in maintaining urinary health. Studies of the urinary microbiota have identified remarkable differences between healthy populations and those with urologic diseases. Microorganisms at sites distal to the kidney… Expand
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319 Citations
Highly Influential Citations
10
Background Citations
80
Methods Citations
9
Results Citations
3

319 Citations

Citation Type

Citation Type

The Urinary Tract Microbiome in Health and Disease.
TLDR
There is a microbiome associated with the healthy urinary tract that can change in urologic disorders and probiotics, prebiotics, and diet modifications appear to represent an opportunity to regulate the urinary microbiome. Expand
Microbiome studies in urology- where do we stand and where can we reach?
TLDR
The role of the urinary microbiome in pathogenesis, diagnosis and treatment of urological conditions and its future prospects are discussed and pondered upon. Expand
The Bladder is Not Sterile: an Update on the Urinary Microbiome
TLDR
The article discusses techniques used to study bacterial urinary microbiota; existence of non-bacterial urinary microbiome; associations between changes in urinary microbiota and various benign lower urinary tract disorders; and additional research can address whether the manipulation of urinary microbiota will benefitLower urinary tract health. Expand
The urinary microbiota: a paradigm shift for bladder disorders?
TLDR
Deeper understanding of the FUM should yield better methods to restore the microbiota to a healthy state, providing symptom relief, and long-standing nomenclature for conditions such as asymptomatic bacteriuria and urinary tract infection will likely require modification. Expand
Modeling of Urinary Microbiota Associated With Cystitis
TLDR
Variations to the UT microbiota of cystitis patients were identified and microbial dynamics has been modeled and protective role of two taxonomic classes of bacteria, Actinobacteria and Bacteroidia class, which appear to actively suppress pathogen overgrowth are indicated. Expand
Microbiome in the urinary system—a review
TLDR
An overview of current findings in urinary microbiome is provided and some of the gaps for future research are discussed, allowing a more holistic approach in the diagnosis, treatment, and prevention of diseases and disorders in urinary system. Expand
The impact of microbiome in urological diseases: a systematic review
TLDR
It is suggested that there might be some relationship between microbiome and various urological diseases, however, further large-scale studies with control of confounding factors should be performed under a standardized methodology to have better understanding of the relationship. Expand
The microbiome and host mucosal interactions in urinary tract diseases.
TLDR
Investigating the impact of the microbiota on the urinary tract in homeostasis and disease including urinary stones, acute kidney injury, chronic kidney disease, and urinary tract infection and proposing new avenues for exploration of the urinary microbiome using emerging technology are proposed. Expand
Overview of Urinary Tract Infections
TLDR
An overview of each type of UTI is provided and some of the most common pathogens involved are discussed along with a brief discussion about themost common pathogenic mechanisms for each. Expand
The human urinary microbiome and how it relates to urogynecology
TLDR
There are significant differences between the microbiota in the lower urinary tract of individuals with urological symptoms and those without, relating to type and proportion of commensal Lactobacillus spp. Expand
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