The microbiome of the urinary tract—a role beyond infection

@article{Whiteside2015TheMO,
  title={The microbiome of the urinary tract—a role beyond infection},
  author={Samantha A. Whiteside and Hassan A. Razvi and Sumit Dave and Gregor Reid and Jeremy P. Burton},
  journal={Nature Reviews Urology},
  year={2015},
  volume={12},
  pages={81-90}
}
Urologists rarely need to consider bacteria beyond their role in infectious disease. However, emerging evidence shows that the microorganisms inhabiting many sites of the body, including the urinary tract—which has long been assumed sterile in healthy individuals—might have a role in maintaining urinary health. Studies of the urinary microbiota have identified remarkable differences between healthy populations and those with urologic diseases. Microorganisms at sites distal to the kidney… 
View on Nature
comenius.susqu.edu
399 Citations
Highly Influential Citations
11
Background Citations
136
Methods Citations
12
Results Citations
9

399 Citations

Questions and challenges associated with studying the microbiome of the urinary tract.

Given the sensitivity of the methodologies employed, and the large potential for contamination when working with low abundance microbiomes, meticulous care in the analyses of urological samples at various sites is required.

Urobiome: An outlook on the metagenome of urological diseases

The urinary tract hosts a complex microbiome that may be indicative of urologic diseases and can be tracked to predict, prevent, and treat them in individuals, but current analytical and sampling collection methods may present limitations.

The Urinary Tract Microbiome in Health and Disease.

The role of microbiome: a novel insight into urolithiasis.

A new front has opened with the evidence for a microbial role in stone formation, offering potential applications in the prevention, and treatment of urolithiasis.

The Urogenital System’s Role in Diseases: A Synopsis

Tackling the urinary microbiome of healthy individuals, as well as its involvement in disease through the proliferation of opportunistic pathogens, could open a potential field of study, leading to new insights into prevention, diagnosis, and treatment strategies for different diseases.

The Bladder is Not Sterile: an Update on the Urinary Microbiome

The article discusses techniques used to study bacterial urinary microbiota; existence of non-bacterial urinary microbiome; associations between changes in urinary microbiota and various benign lower urinary tract disorders; and additional research can address whether the manipulation of urinary microbiota will benefitLower urinary tract health.

Bladder Microbiome in the Context of Urological Disorders—Is There a Biomarker Potential for Interstitial Cystitis?

The new insights into the bladder microbiome and its potential influence on urologic disease cannot yet be used in the context of elucidating possible etiopathogenetic causes, as well as in the use of a biomarker for diagnostic or prognostic purposes.

The urinary microbiome and biological therapeutics: Novel therapies for urinary tract infections.

Emerging Role of Microbiome in the Prevention of Urinary Tract Infections in Children

The healthy urobiome in children, the role of dysbiosis in urinary tract infection, and the strategies to modification and reshape disease-prone microbiomes in pediatric patients with recurrent urinary tract infections are summarized.

A Perspective of the Urinary Microbiome in Lower Urinary Tract Infections — A Review

This review discusses internal and external influences that promote either a balance or a dysbiosis of the urinary tract and the future perspectives in understanding lower urinary tract infections.
...

References

SHOWING 1-10 OF 168 REFERENCES

Mini-review: perspective of the microbiome in the pathogenesis of urothelial carcinoma.

Emerging data suggest that indigenous microbiota in the urinary tract may play an important role in the tumorigenesis of urothelial carcinoma, similar to other tumors.

Human Microbiota Characterization in the Course of Renal Transplantation

  • W. F. FrickeC. MaddoxY. SongJ. Bromberg
  • Biology, Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2014
Investigating the longitudinal changes in the blood, urinary, oral and rectal microbiota of renal allograft recipients before and at 1 and 6 months after transplantation showed major changes in microbiota composition as a result of the transplant episode and associated medications, and these changes persisted over time.

The Female Urinary Microbiome: a Comparison of Women with and without Urgency Urinary Incontinence

This study compared the urinary microbiomes of women affected by UUI to those of a comparison group without UUI, using both high-throughput sequencing and extended culture techniques, and identified statistically significant differences in the frequency and abundance of bacteria present.

Characteristic Male Urine Microbiomes Associate with Asymptomatic Sexually Transmitted Infection

Urine microbiomes from men with STI were dominated by fastidious, anaerobic and uncultivated bacteria, and the same taxa were rare in STI negative individuals.

The Placenta Harbors a Unique Microbiome

A unique placental microbiome niche was characterized, composed of nonpathogenic commensal microbiota from the Firmicutes, Tenericute, Proteobacteria, Bacteroidetes, and Fusobacteria phyla, which was consistently different from those reported in other parts of the body, including the skin and urogenital tract.

The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults

It is concluded that a “core” urinary microbiome could potentially exist, when samples are grouped by age with fluctuation in abundance between age groups, and conventional microbiological methods are inadequate to fully identify around two-thirds of the bacteria identified in this study.

Alterations of microbiota in urine from women with interstitial cystitis

This study demonstrates that high throughput sequencing analysis of urine microbiota in IC patients is a powerful tool towards a better understanding of this enigmatic disease.

The Colon: An Overlooked Site for Therapeutics in Dialysis Patients

Several therapeutic interventions, including prebiotics and adsorbants, specifically target these colon‐derived uremic toxins originating from bacterial metabolism, which may accelerate the progression of renal and cardiovascular disease.

[Gut microbiota in health and disease].

Temporal Dynamics of the Human Vaginal Microbiota

The temporal dynamics of the composition of vaginal bacterial communities in 32 reproductive-age women over a 16-week period revealed the dynamics of five major classes of bacterial communities and showed that some communities change markedly over short time periods, whereas others are relatively stable.
...