The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

@inproceedings{Changa2014TheMM,
  title={The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition},
  author={Pamela V. Changa and Liming Haob and Stefan Offermannsc and Ruslan Medzhitova},
  year={2014}
}
  • Pamela V. Changa, Liming Haob, +1 author Ruslan Medzhitova
  • Published 2014
Given the trillions of microbes that inhabit the mammalian intestines, the host immune system must constantly maintain a balance between tolerance to commensals and immunity against pathogens to avoid unnecessary immune responses against otherwise harmless bacteria. Misregulated responses can lead to inflammatory bowel diseases such as ulcerative colitis or Crohn’s disease. The mechanisms by which the immune system maintains this critical balance remain largely undefined. Here, we demonstrate… CONTINUE READING
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