The microaerophilic flagellate Giardia intestinalis: oxygen and its reaction products collapse membrane potential and cause cytotoxicity.

@article{Lloyd2000TheMF,
  title={The microaerophilic flagellate Giardia intestinalis: oxygen and its reaction products collapse membrane potential and cause cytotoxicity.},
  author={David Lloyd and Janine C Harris and Sarah L Maroulis and Giancarlo A Biagini and Robert B. Wadley and Michael Patrick Turner and Michael R. Edwards},
  journal={Microbiology},
  year={2000},
  volume={146 Pt 12},
  pages={3109-18}
}
Trophozoites of the microaerophilic flagellate parasitic protozoon Giardia intestinalis have only a limited capacity to detoxify O(2). Thus, when exposed to controlled concentrations of dissolved O(2) >8 microM, they gradually lose their ability to scavenge O(2). In a washed cell suspension stirred under 10% air in N(2) (equivalent to 25 microM O(2)), inactivation of the O(2)-consuming system was complete after 3.5 h; during this period accumulation of H(2)O(2) (3 micromol per 10(6) organisms… CONTINUE READING

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