The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis.

@article{Leidner2012TheMM,
  title={The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis.},
  author={Rom S. Leidner and Lakshmeswari Ravi and P. Michael Leahy and Yanwen Chen and Beth A Bednarchik and Mirte Mayke Streppel and Marcia Canto and Jean S. Wang and Anirban Maitra and Joseph Willis and Sanford D Markowitz and Jill S. Barnholtz-Sloan and Mark D. Adams and Amitabh Chak and Kishore Guda},
  journal={Genes, chromosomes & cancer},
  year={2012},
  volume={51 5},
  pages={473-9}
}
There is a critical need to identify molecular markers that can reliably aid in stratifying esophageal adenocarcinoma (EAC) risk in patients with Barrett's esophagus. MicroRNAs (miRNA/miR) are one such class of biomolecules. In the present cross-sectional study, we characterized miRNA alterations in progressive stages of neoplastic development, i.e., metaplasia-dysplasia-adenocarcinoma, with an aim to identify candidate miRNAs potentially associated with progression. Using next generation… CONTINUE READING

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