The microRNA regulatory network in normal- and HTLV-1-transformed T cells.

@article{DAgostino2012TheMR,
  title={The microRNA regulatory network in normal- and HTLV-1-transformed T cells.},
  author={Donna M. D'Agostino and Paola Zanovello and Toshiki Watanabe and Vincenzo Ciminale},
  journal={Advances in cancer research},
  year={2012},
  volume={113},
  pages={
          45-83
        }
}
Recent efforts to understand the molecular networks governing normal T cell development and driving the neoplastic transformation of T cells have brought to light the involvement of microRNAs (miRNAs), a class of noncoding RNAs of approximately 22 nucleotides that regulate gene expression at the posttranscriptional level. In the present review, we compare the expression profiles of miRNAs in normal T cell development to that of transformed T cells using as a model adult T cell leukemia/lymphoma… CONTINUE READING
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