The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

@article{Stittrich2010TheMM,
  title={The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes},
  author={Anna-Barbara Stittrich and Claudia Haftmann and Evridiki Sgouroudis and Anja Andrea K{\"u}hl and Ahmed Nabil Hegazy and Isabel Panse and Rene Riedel and Michael Flossdorf and Jun Dong and Franziska Fuhrmann and Gitta Anne Heinz and Zhuo Fang and Na Li and Ute Bissels and Farahnaz Hatam and Angelina Jahn and Ben Hammoud and Mareen Matz and Floris Schulze and Ria Baumgrass and Andreas Bosio and Hans-Joachim Mollenkopf and J Tassilo Gr{\"u}n and Andreas Thiel and Wei Chen and Thomas H{\"o}fer and Christoph Loddenkemper and Max L{\"o}hning and Hyun-Dong Chang and Nikolaus Rajewsky and Andreas Radbruch and Mir-Farzin Mashreghi},
  journal={Nature Immunology},
  year={2010},
  volume={11},
  pages={1057-1062}
}
After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor–mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited… CONTINUE READING
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FOXO1 is a FOXO target gene

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