The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans

@inproceedings{Clark2010TheMM,
  title={The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans},
  author={Alejandra M. Clark and Leonard D. Goldstein and Maya Tevlin and Simon Tavar{\'e} and Shai Shaham and Eric A Miska},
  booktitle={Nucleic acids research},
  year={2010}
}
miR-124 is a highly conserved microRNA (miRNA) whose in vivo function is poorly understood. Here, we identify miR-124 targets based on the analysis of the first mir-124 mutant in any organism. We find that miR-124 is expressed in many sensory neurons in Caenorhabditis elegans and onset of expression coincides with neuronal morphogenesis. We analyzed the transcriptome of miR-124 expressing and nonexpressing cells from wild-type and mir-124 mutants. We observe that many targets are co-expressed… CONTINUE READING

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