The microRNA-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids

@inproceedings{Agudo2014TheMA,
  title={The microRNA-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids},
  author={Judith Agudo and Albert Ruzo and Navpreet Singh Tung and H{\'e}l{\`e}ne Salmon and Maryl{\`e}ne Leboeuf and Daigo Hashimoto and Christian D K Becker and Lee-Ann Garrett-Sinha and Alessia Baccarini and Miriam Merad and Brian D. Brown},
  booktitle={Nature Immunology},
  year={2014}
}
miR-126 is a microRNA expressed predominately by endothelial cells and controls angiogenesis. We found miR-126 was required for the innate response to pathogen-associated nucleic acids and that miR-126-deficient mice had greater susceptibility to infection with pseudotyped HIV. Profiling of miRNA indicated that miR-126 had high and specific expression by plasmacytoid dendritic cells (pDCs). Moreover, miR-126 controlled the survival and function of pDCs and regulated the expression of genes… CONTINUE READING
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