The miRNome of Alzheimer's disease: consistent downregulation of the miR-132/212 cluster.

@article{Pichler2017TheMO,
  title={The miRNome of Alzheimer's disease: consistent downregulation of the miR-132/212 cluster.},
  author={Sabrina Pichler and Wei Wang Gu and Daniela Hartl and Gilles Gasparoni and Petra Leidinger and Andreas Keller and Eckart Meese and Manuel Mayhaus and Harald Hampel and Matthias Riemenschneider},
  journal={Neurobiology of aging},
  year={2017},
  volume={50},
  pages={
          167.e1-167.e10
        }
}
MicroRNAs (miRNAs) are small noncoding RNA molecules, with essential functions in RNA silencing and post-transcriptional regulation of gene expression. miRNAs appear to regulate the development and function of the nervous system. Alterations of miRNA expression have been associated with Alzheimer's disease (AD). To characterize the AD miRNA signature, we examined genome-wide miRNA and mRNA expression patterns in the temporal cortex of AD and control samples. We validated our miRNA results by… CONTINUE READING
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