The miRNA pathway in neurological and skeletal muscle disease: implications for pathogenesis and therapy

@article{Sibley2011TheMP,
  title={The miRNA pathway in neurological and skeletal muscle disease: implications for pathogenesis and therapy},
  author={Christopher R. Sibley and Matthew J. Wood},
  journal={Journal of Molecular Medicine},
  year={2011},
  volume={89},
  pages={1065-1077}
}
RNA interference (RNAi) represents a powerful post-transcriptional gene silencing network which fine-tunes gene expression in all eukaryotic cells. The endogenous triggers of RNAi, microRNAs (miRNAs), are proposed to regulate expression of up to a third of all protein-coding genes, and have been shown to have critical roles in developmental processes including in the central nervous system and skeletal muscle. Further, many have been reported to display differential expression in various… CONTINUE READING
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Distinctive patterns of microRNA expression in primary muscular disorders

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  • Proc Natl Acad Sci U S A
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