The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma.

Abstract

miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.

DOI: 10.18632/oncotarget.6257

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Cite this paper

@article{Liu2015TheMP, title={The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma.}, author={Rui Liu and Haiyang Zhang and Xia Wang and Likun Zhou and Hongli Li and Ting Deng and Yanjun Qu and Jingjing Duan and Ming Bai and Shaohua Ge and Tao Ning and Le Zhang and Dingzhi Huang and Yi Ba}, journal={Oncotarget}, year={2015}, volume={6 41}, pages={43831-42} }