The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma.

Abstract

miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.

DOI: 10.18632/oncotarget.6257

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Showing 1-10 of 31 references

The Impact of Preoperative Radiation Therapy on Locoregional Recurrence in Patients with Stage IV Rectal Cancer Treated with Definitive Surgical Resection and Contemporary Chemotherapy

  • Bv Manyam, Ih Mallick, +6 authors Sa
  • 2015

Cancer statistics CA: a cancer journal for clinicians

  • R Siegel, J Ma, Z Zou, A Jemal
  • 2014