The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression.

  title={The miR-200 family regulates TGF-$\beta$1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression.},
  author={Mingxia Xiong and Lei Jiang and Yang Zhou and Wenjing Qiu and Li Fang and Rouyun Tan and Ping Wen and Junwei Yang},
  journal={American journal of physiology. Renal physiology},
  volume={302 3},
Most chronic kidney injuries inevitably progress to irreversible renal fibrosis. Tubular epithelial-to-mesenchymal transition (EMT) is recognized to play pivotal roles in the process of renal fibrosis. However, a comprehensive understanding of the pathogenesis of renal scar formation and progression remains an urgent task for renal researchers. The endogenously produced microRNAs (miRNAs), proved to play important roles in gene regulation, probably regulate most genes involved in EMT. In this… 

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Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention.

  • Youhua Liu
  • Biology, Medicine
    Journal of the American Society of Nephrology : JASN
  • 2004
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