The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.

  title={The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.},
  author={Tamar Uziel and Fedor V. Karginov and Suqing Xie and Joel S. Parker and Yong-Dong Wang and Amar Gajjar and Lin He and David Ellison and Richard J. Gilbertson and Gregory R Hannon and Martine F Roussel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 8},
Medulloblastomas (MBs) are the most common brain tumors in children. Some are thought to originate from cerebellar granule neuron progenitors (GNPs) that fail to undergo normal cell cycle exit and differentiation. Because microRNAs regulate numerous aspects of cellular physiology and development, we reasoned that alterations in miRNA expression might contribute to MB. We tested this hypothesis using 2 spontaneous mouse MB models with specific initiating mutations, Ink4c-/-; Ptch1+/- and Ink4c… CONTINUE READING
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