The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

  title={The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities},
  author={D{\'e}sir{\'e}e Bonci and Valeria Coppola and Maria Musumeci and A. P. D ' Addario and Raffaella Giuffrida and Lorenzo Memeo and Leonardo D'Urso and Alfredo Pagliuca and Mauro Biffoni and Catherine Labbaye and Monica Bartucci and Giovanni Muto and Cesare Peschle and Ruggero De Maria},
  journal={Nature Medicine},
MicroRNAs (miRNAs) are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs. miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2. These miRNAs form a cluster at the chromosomal region 13q14, which is frequently deleted in cancer. Here, we report that the miR-15a and miR-16-1 cluster targets CCND1 (encoding cyclin D1) and WNT3A, which promotes several tumorigenic features such as survival, proliferation and invasion. In… CONTINUE READING
Highly Influential
This paper has highly influenced 29 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 404 extracted citations

miRNAs associated with prostate cancer risk and progression

BMC urology • 2017
View 5 Excerpts
Highly Influenced

MicroRNA in central nervous system trauma and degenerative disorders.

Physiological genomics • 2011
View 10 Excerpts
Highly Influenced

MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease

Immune network • 2011
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 40 references

competitive inhibitors of small RNAs in mammalian cells

M. S. Ebert, J. R. Neilson, Sharp, P. A. MicroRNA sponges
Nat. Methods 4, 721–726 • 2007

expression and localization in archival human brain

B. P. Lewis, C. B. Burge, D. P. Bartel

A phase II, pharmacokinetic, and biological correlative study of oblimersen sodium and docetaxel in patients with hormone-refractory prostate cancer

Tolcher, A.W
Clin. Cancer Res • 2005

Similar Papers

Loading similar papers…