The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis.

@article{Deacon2010TheMP,
  title={The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis.},
  author={Dekker C Deacon and Kathleen Rae Nevis and Timothy J. Cashman and Yong Zhou and Long Zhao and Daniel Washko and Burcu Guner-Ataman and Charles Geoffrey Burns and Caroline Erter Burns},
  journal={Development},
  year={2010},
  volume={137 11},
  pages={
          1887-96
        }
}
Discovering the genetic and cellular mechanisms that drive cardiac morphogenesis remains a fundamental goal, as three-dimensional architecture greatly impacts functional capacity. During development, accurately contoured chambers balloon from a primitive tube in a process characterized by regional changes in myocardial cell size and shape. How these localized changes are achieved remains elusive. Here, we show in zebrafish that microRNA-143 (miR-143) is required for chamber morphogenesis… CONTINUE READING
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SHOWING 1-10 OF 53 REFERENCES

The anatomy of cardiac looping : a step towards the understanding of the morphogenesis of several forms of congenital cardiac malformations

  • J. Manner
  • Clin . Anat .
  • 2009

miRNA in situ hybridization in formaldehyde and EDC - fixed tissues

  • J. T. Pena, C. Sohn-Lee, +7 authors M. Zavolan
  • Nat . Methods
  • 2009

The emerging role of microRNAs in cardiac remodeling and heart failure

  • R. R. Markwald, V. Divakaran, D. L. Mann
  • Circ . Res .
  • 2008

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