The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer

@inproceedings{Villadsen2012TheMC,
  title={The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer},
  author={Sune B. Villadsen and Jasper Bertram Bramsen and Marie Stampe Ostenfeld and Erik D. Wiklund and Niels Fristrup and Shengjie Gao and Thomas B Hansen and Trine I. Jensen and Michael Borre and Torben F. \Orntoft and Lars Dyrskj\ot and J\orgen Kjems},
  booktitle={British Journal of Cancer},
  year={2012}
}
Background:Upregulation of the proto-oncogene plasminogen activator inhibitor-1 (PAI-1) is a common hallmark of various solid tumours, but the mechanisms controlling its expression are not fully understood.Methods:We investigate microRNAs (miRNAs) regulating PAI-1 in a panel of normal bladder urothelial biopsies, superficial Ta bladder tumours and invasive T1–T4 tumours using expression microarrays and qRT–PCR. The prognostic implications of PAI-1 deregulation are established by tissue… CONTINUE READING
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