The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

@inproceedings{Smith2012TheMC,
  title={The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer},
  author={Anna L. Smith and Ritsuko Iwanaga and David J. Drasin and Douglas S. Micalizzi and Rebecca L. Vartuli and Aik Choon Tan and Heide L. Ford},
  booktitle={Oncogene},
  year={2012}
}
The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this elusive ‘TGF-β paradox’. Herein, we identify a mechanism by which Six1 activates the tumor promotional arm of TGF-β signaling, via its ability to upregulate the miR-106b-25 microRNA cluster, and further identify a novel function for this cluster of… CONTINUE READING
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