The mevalonate pathway during acute tubular injury: selected determinants and consequences.

@article{Zager2002TheMP,
  title={The mevalonate pathway during acute tubular injury: selected determinants and consequences.},
  author={Richard A Zager and Vallabh O. Shah and Hemangini V Shah and Philip G. Zager and Ali C. M. Johnson and Sherry Y. Hanson},
  journal={The American journal of pathology},
  year={2002},
  volume={161 2},
  pages={681-92}
}
Renal injury evokes tubular cholesterol accumulation, mediated in part by increased HMG CoA reductase (HMGCR) levels. The present study was undertaken to define potential molecular determinants of these changes and to ascertain the relative importance of increased cholesterol production versus mevalonate pathway-driven protein prenylation, on the emergence of the so-called postrenal injury "cytoresistant state." Cultured proximal tubule (HK-2) cells were subjected to Fe or ATP depletion injury… CONTINUE READING