The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA.

@article{Toh2008TheMY,
  title={The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA.},
  author={S Toh and Liqun Xiong and Taeok Bae and Alexander S Mankin},
  journal={RNA},
  year={2008},
  volume={14 1},
  pages={98-106}
}
A2503 in 23S rRNA of the gram-negative bacterium Escherichia coli is located in a functionally important region of the ribosome, at the entrance to the nascent peptide exit tunnel. In E. coli, and likely in other species, this adenosine residue is post-transcriptionally modified to m2A. The enzyme responsible for this modification was previously unknown. We identified E. coli protein YfgB, which belongs to the radical SAM enzyme superfamily, as the methyltransferase that modifies A2503 of 23S… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

Structural studies of viperin, an antiviral radical SAM enzyme.

Proceedings of the National Academy of Sciences of the United States of America • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…