The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

  title={The methyltransferase G9a regulates HoxA9-dependent transcription in AML.},
  author={Bernhard Lehnertz and Caroline Pabst and L i Su and Michelle Miller and Feng Liu and Lin Yi and Regan H Zhang and Jana Krosl and Eric M Yung and Jeanette Kirschner and Patty M Rosten and T. Michael Underhill and Jian Jin and J. -L. Hebert and Guy Sauvageau and Richard Keith Humphries and Fabio M.V. Rossi},
  journal={Genes & development},
  volume={28 4},
Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological inhibition. Here we establish the histone methyltransferase G9a/EHMT2 as a selective regulator of fast proliferating myeloid progenitors with no discernible function in hematopoietic stem cells (HSCs). In mouse models of acute myeloid leukemia (AML), loss of G9a significantly delays disease progression and reduces leukemia stem cell (LSC… CONTINUE READING