The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.

@article{Cassera2004TheMP,
  title={The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.},
  author={Maria Belen Cassera and Fabio Cesar Gozzo and Fabio Luiz D'Alexandri and Emilio F. Merino and Hernando A Del Portillo and Valnice Jesus Peres and Igor C. Almeida and Marcos Nogueira Eberlin and Gerhard Wunderlich and Jochen Wiesner and Hassan Jomaa and Em{\'i}lia Akemi Kimura and Alejandro Miguel Katzin},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 50},
  pages={51749-59}
}
Two genes encoding the enzymes 1-deoxy-D-xylulose-5-phosphate synthase and 1-deoxy-D-xylulose-5-phosphate reductoisomerase have been recently identified, suggesting that isoprenoid biosynthesis in Plasmodium falciparum depends on the methylerythritol phosphate (MEP) pathway, and that fosmidomycin could inhibit the activity of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. The metabolite 1-deoxy-D-xylulose-5-phosphate is not only an intermediate of the MEP pathway for the biosynthesis of… CONTINUE READING

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