The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma.

Abstract

FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors. In this study, we investigated the FBXW7 gene in human thymoma; although no mutations were evident, a significantly high frequency of methylation in the FBXW7 beta-form promoter was observed in types B1 or higher (P=0.014). We propose a novel mechanism for the pathogenesis of thymoma by FBXW7 beta-form and hypothesize that expressional suppression plays an important role in the malignant potential of thymoma.

DOI: 10.1016/j.bbrc.2008.10.047

Cite this paper

@article{Gu2008TheMS, title={The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma.}, author={Zhaodi Gu and Hidetoshi Mitsui and Kenichi Inomata and Masako Honda and Chiaki Endo and Akira Sakurada and Masami Sato and Yoshinori Okada and Takashi Kondo and Akira Horii}, journal={Biochemical and biophysical research communications}, year={2008}, volume={377 2}, pages={685-688} }