The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis?

@article{Kobow2011TheMH,
  title={The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis?},
  author={Katja Kobow and Ingmar Bl{\"u}mcke},
  journal={Epilepsia},
  year={2011},
  volume={52 Suppl 4},
  pages={15-9}
}
Any structural brain lesion can provoke epilepsy, although onset and progression of seizures as well as response to antiepileptic drug (AED) treatment remain difficult to predict in each patient. Tremendous work has focused on the development of new AED compounds with the intention to treat seizures. However, these efforts have not yet discovered a "magic bullet" that cures epilepsy in every patient or modifies disease progression. With the "methylation hypothesis" we propose that epigenetic… CONTINUE READING

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