The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE(-/-) mice.

@article{Mercer2012TheMX,
  title={The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE(-/-) mice.},
  author={John R. Mercer and Kelly M Gray and Nichola 4 Figg and Sheetal R. Kumar and Martin R. Bennett},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2012},
  volume={32 10},
  pages={
          2461-7
        }
}
OBJECTIVE Caffeine remains one of the most widely consumed drugs in the world. Caffeine has multiple actions, including inhibition of the DNA damage response, and its metabolites, 1-methylxanthine and 1-methyluric acid, are potent antioxidants. Combined, these properties can exert direct effects on cell proliferation, cell death, inflammation, and DNA repair, all important processes that occur in atherosclerosis. METHODS AND RESULTS We first examined the effects of caffeine on mouse vascular… CONTINUE READING
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