The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA.

@article{Chandler1999TheMB,
  title={The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA.},
  author={Sondra Chandler and Dmitry Guschin and Nicoletta Landsberger and Alan P. Wolffe},
  journal={Biochemistry},
  year={1999},
  volume={38 22},
  pages={7008-18}
}
We have investigated the interactions of the methyl-CpG binding transcriptional repressor MeCP2 with nucleosomal DNA. We find that MeCP2 forms discrete complexes with nucleosomal DNA associating with methyl-CpGs exposed in the major groove via the methyl-CpG-binding domain (MBD). In addition to the MBD, the carboxyl-terminal segment of MeCP2 facilitates binding both to naked DNA and to the nucleosome core. These observations provide a molecular mechanism by which MeCP2 can gain access to… CONTINUE READING

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