The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.

@article{Fuks2003TheMP,
  title={The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.},
  author={François Fuks and Paul J Hurd and Daniel Wolf and Xinsheng Nan and Adrian Bird and Tony Kouzarides},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 6},
  pages={4035-40}
}
DNA methylation plays an important role in mammalian development and correlates with chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG dinucleotides represents a major mechanism by which DNA methylation can repress transcription. MeCP2 silences gene expression partly by recruiting histone deacetylase (HDAC) activity, resulting in chromatin remodeling. Here, we show that MeCP2 associates with histone methyltransferase activity in vivo and that this activity is… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS