The methods of synthesis, modification, and biological activity of 4-quinolones (review)

@article{Boteva2009TheMO,
  title={The methods of synthesis, modification, and biological activity of 4-quinolones (review)},
  author={Antoaneta Boteva and Olga P. Krasnykh},
  journal={Chemistry of Heterocyclic Compounds},
  year={2009},
  volume={45},
  pages={757-785}
}
Data on methods for the construction of the 4-quinolone skeleton and modification of the substituents around it are reviewed. The “structure–activity” relationships of 4-quinolones are examined with respect to antibacterial and antitumor activity. 
View on Springer
84 Citations
Highly Influential Citations
1
Background Citations
6

84 Citations

Citation Type

Citation Type

Synthesis and Biological Activities of Selected Quinolone-Metal Complexes
TLDR
In this review article, synthesis and biological activity of metal complexes of selected 4-quinolones such as norfloxacin, ciprofloxAcin, enrofloxin, gatifloxacIn, and sparfloxACin are presented and discussed.
Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones
Fluoroquinolones: Synthesis and Application
The data on 6-fluorо-1,4-dihydroquinolin-4-oxo-3-carboxylic acids and their structural analogues accumulated in the literature for the last 10–15 years are reviewed. Synthetic approaches to the…
Structural assignment of the enol–keto tautomers of one-pot synthesized 4-hydroxyquinolines/4-quinolones
The one-pot preparation of 2,3-disubstituted 4-quinolones and the structural assignment of their tautomers are described.
Recent Advances in the Catalytic Synthesis of 4-Quinolones
N-(2-Aminobenzoyl)benzotriazole mediated and t-BuOK promoted synthesis of 2-substituted quinolone 3-carboxylates
Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications
TLDR
In this account, the development of new methods for the synthesis of 1,2,3‐triazoles and the preparation of new triazole‐functionalized biologically active molecules using classical approaches are discussed.
A short and divergent route to 2-alkenyl-4-quinolones
Application of 9-ethyl[1,2,5]selenadiazolo[3,4-h]quinolones in the synthesis of tricyclic azoloquinolones
Synthesis of novel 1-hydroxyquinolones with high anti-toxoplasma activity
All for the treatment of malaria and toxoplasmosis the novel hydroxyquinolones 2-5 were prepared by reaction of aniline and hydroxyaniline, respectively and the β-ketoesters 10a-c. As products the…
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 78 REFERENCES
A convenient method for the synthesis of 3,5,7-trimethoxy-2-phenyl-4-quinolones
Synthesis and biological activities of truncated acridone: Structure-activity relationship studies of cytotoxic 5-hydroxy-4-quinolone
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Synthesis of γ-and δ-lactones derived from 4-quinolone-3-carboxylic acid
Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones 1 1 Part of the
Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones.
Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents.
Novel and convenient synthesis of 4(1H)quinolones
A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.
TLDR
The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described and is characterized by relatively low reaction temperature and ease of product isolation.
Synthesis of Fluorinated 1,3,4-Oxadiazino[6,5,4-i,j]quinolines
Abstract3-(2-Acylhydrazino)-2-tetra(penta)fluorobenzoylacrylates are readily converted to acylamino-substituted quinolones and, under more forcing conditions, annelation of oxadiazine ring occurs. We…
...
1
2
3
4
5
...