Corpus ID: 90839962

The methods and compositions for increasing the alpha-L-iduronidase activity of the central nervous system

@inproceedings{2008TheMA,
  title={The methods and compositions for increasing the alpha-L-iduronidase activity of the central nervous system},
  author={ウィリアム・エム・パードリッジ and ルーベン・ジェイ・ボアド},
  year={2008}
}
The present invention provides methods and compositions for treating a subject afflicted with alpha-L-iduronidase deficiency in CNS. The method comprises the systemic administration of bifunctional fusion antibody comprising an antibody against human insulin receptor and alpha-L-iduronidase. Therapeutically effective systemic dose, based on the specific CNS uptake characteristics of human insulin receptor antibody-.alpha.-L-iduronidase fusion antibodies described herein.