The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity.

@article{Linnebank2005TheMS,
  title={The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity.},
  author={Michael Linnebank and Klaus Fliessbach and Heike Kolsch and Marcella Rietschel and Ullrich Wullner},
  journal={International journal of molecular medicine},
  year={2005},
  volume={16 4},
  pages={759-61}
}
The functional polymorphism methionine synthase (MTR) c.2576A-->G (D919G) influences homocysteine and folate metabolism and has been reported to be of protective function against oncological, neurodegenerative and vascular diseases. We analyzed 329 healthy individuals to confirm whether this polymorphism might be of epidemiological impact on disease-free longevity. In our sample, prevalence of the G-allele was significantly higher in the older than in the younger individuals (p=0.005… CONTINUE READING

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