The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma

@article{Linnebank2004TheMS,
  title={The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma},
  author={Michael Linnebank and Stephan Schmidt and Heike Kolsch and Anja Linnebank and Reinhard Heun and Ingo G. H. Schmidt-Wolf and Axel G Glasmacher and Klaus Fliessbach and Thomas Klockgether and Uwe Schlegel and Hendrik Pels},
  journal={British Journal of Cancer},
  year={2004},
  volume={90},
  pages={1969 - 1971}
}
Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI95%: 0.09–0.74; P=0.005), suggesting a protective function of the G allele. These data… CONTINUE READING

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Primary CNS lymphoma : results of a pilot / phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy

H Pels, Schmidt-Wolf IGH, +17 authors U Schlegel
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Primary CNS lymphoma: results of a pilot/phase II study of systemic and intraventricular

H Pels, IGH Schmidt-Wolf, +17 authors U Schlegel
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