The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance.

@article{Rinella2004TheMD,
  title={The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance.},
  author={Mary Eugenia Rinella and Richard M. Green},
  journal={Journal of hepatology},
  year={2004},
  volume={40 1},
  pages={47-51}
}
BACKGROUND/AIMS Non-alcoholic steatohepatitis is an important disease whose pathophysiology remains incompletely understood, although in humans a strong association with insulin resistance exists. Mice fed a methionine-choline deficient (MCD) diet develop steatohepatitis, however the influence of insulin in this model is unknown. METHODS Male FVB/NJ mice were fed the MCD, MCD control or chow diet for 10 or 28 days. Fasting glucose, ALT, triglyceride and insulin was measured. Glucose tolerance… CONTINUE READING

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