The methionine-aromatic motif plays a unique role in stabilizing protein structure.

@article{Valley2012TheMM,
  title={The methionine-aromatic motif plays a unique role in stabilizing protein structure.},
  author={Christopher C. Valley and Alessandro Cembran and Jason D. Perlmutter and A. Kelsey Lewis and Nicholas P Labello and Jiali Gao and Jonathan N. Sachs},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 42},
  pages={34979-91}
}
Of the 20 amino acids, the precise function of methionine (Met) remains among the least well understood. To establish a determining characteristic of methionine that fundamentally differentiates it from purely hydrophobic residues, we have used in vitro cellular experiments, molecular simulations, quantum calculations, and a bioinformatics screen of the Protein Data Bank. We show that approximately one-third of all known protein structures contain an energetically stabilizing Met-aromatic motif… CONTINUE READING
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